Mitochondria and Chronic Fatigue: What I Learned About Migraines Today

Are the mitochondria responsible for chronic fatigue?

These little organisms live inside our cells and generate chemical energy, called ATP. ATP is what our bodies use to power the cells.

When the mitochondria don’t function optimally, they don’t create enough energy. The result: you are exhausted right down to your cells. You don’t have the energy to move, to think, to breathe.

Mitochondria and Chronic Fatigue

This short video explains how malfunctions in the mitochondria fit into the big picture of chronic fatigue. In the video, Dr. Justin Marchegiani describes how the mitochondria work, the process they use to create energy, and the nutrients involved in this process.

What I Learned About Migraines Today

The first thing that jumped out at me from this video is the star-shaped diagram Dr. Marchegiani uses to describe how chronic fatigue works. The star is composed of two triangles. One triangle links the mitochondria, adrenal glands, and thyroid gland because of their roles in determining our energy levels. The other triangle links the brain, liver, and gut because these organs each impact the process. Overlaying the two triangles creates a cycle of interacting factors that contribute to chronic fatigue.

This little diagram hits all the key points to depict chronic fatigue. The mitochondria, adrenals, thyroid, brain, liver, and gut all need to be working efficiently. They are all links in a chain that can be broken at the weakest link.

To me, what is most fascinating about this diagram is that the adrenals, thyroid, brain, liver, and gut are all involved in migraines. Adding the mitochondria to the picture fills in a missing piece of the puzzle.

Another thing that really struck me when watching this video is the discussion of nutrients involved in generating energy. Magnesium, B vitamins, iron, ALA, CoQ10, and amino acids are all used by the mitochondria as they create ATP. Each of these nutrients will help control migraines in some people.

The video also mentions that toxicity is one of the main reasons the mitochondria will malfunction. Dr. Marchegiani mentions that adding extra nutrients is the easiest way to combat toxicity at the cellular level.

If you have a few minutes, please check out the video and let me know whether you learned anything from it!

Credits: Image by RegisFrey (Own work) [CC BY 3.0 (], via Wikimedia Commons



Leave a Comment