Mitochondrial DNA and Migraines: What I Learned About Migraines Today

PubMed lists 67301 papers about mitochondrial DNA. Of those, 113 come up with the added keyword “migraine”.

I learned right away right away that:

Certain mitochondrial DNA (mtDNA) variants and haplogroups have been found to be associated with neurological disorders … by affecting the ATP production on high-energy demanding organs, such as the brain. (1)

The rest of today’s post includes a bunch of interesting papers I will need to explore further.

Mitochondrial DNA Mutations Associated with Migraines

Prevalence of migraine in persons with the 3243A>G mutation in mitochondrial DNA.

Increased prevalence of two mitochondrial DNA polymorphisms in functional disease: Are we describing different parts of an energy-depleted elephant?

Two common mitochondrial DNA polymorphisms are highly associated with migraine headache and cyclic vomiting syndrome.

Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs.

Review Papers on Mitochondrial DNA and Migraines

A possible role for mitochondrial dysfunction in migraine.

Mitochondrial Disorders Overview

Mitochondrial Dysfunction in Migraine

Epigenetics and migraine; complex mitochondrial interactions contributing to disease susceptibility.

Sex ratios and mitochondrial genetics in migraine.

Adult mitochondrial DNA depletion syndrome with mild manifestations.

What I learned about migraines today

  1. The association between migraines and mitochondrial DNA is being studied extensively.
  2. I have a lot of reading to do!


(1) No evidence of association between common European mitochondrial DNA variants in Alzheimer, Parkinson, and migraine in the Spanish population.


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